Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells

Cancer stem cells (CSCs) exhibit tumorigenic potential and can generate resistance to chemotherapy and radiotherapy. A labeled ornithine decarboxylase (ODC, a rate-limiting enzyme involved in polyamine [PA] biosynthesis) degradation motif (degron) system allows visualization of a fraction of CSC-lik...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Tamari, Keisuke, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Hayashi, Kazuhiko, Kawamoto, Koichi, Murai, Noriyuki, Matsufuji, Senya, Isohashi, Fumiaki, Satoh, Taroh, Goto, Noriko, Tanaka, Shinji, Doki, Yuichiro, Mori, Masaki, Ogawa, Kazuhiko, Ishii, Hideshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234213/
https://ncbi.nlm.nih.gov/pubmed/30455990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0117-7
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