Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2

Many anticancer drugs have serious adverse effects; therefore, it is necessary to target features specific to cancer cells to minimize the effects on healthy cells. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was reported to be specifically enhanced in cancer. We confirmed the validity of MTH...

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Publicado no:Heliyon
Main Authors: Asai, Ayumu, Koseki, Jun, Konno, Masamitsu, Nishimura, Tatsunori, Gotoh, Noriko, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299143/
https://ncbi.nlm.nih.gov/pubmed/30582043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e01021
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