WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and whether cells maintain a memory of their signaling history remains obscure. Here, we dissect the temporal integration of two key pathways, WNT and...

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Pubblicato in:eLife
Autori principali: Yoney, Anna, Etoc, Fred, Ruzo, Albert, Carroll, Thomas, Metzger, Jakob J, Martyn, Iain, Li, Shu, Kirst, Christoph, Siggia, Eric D, Brivanlou, Ali H
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234031/
https://ncbi.nlm.nih.gov/pubmed/30311909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38279
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