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Self-organization of a human organizer by combined WNT and NODAL signalling

In amniotes, the development of the primitive streak (PS) and its accompanying “organizer” define the first stages of gastrulation. Despite detailed characterization in model organisms, the analogous human structures remain a mystery. We have previously shown that when stimulated with BMP4, micropat...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Martyn, I., Kanno, T.Y., Ruzo, A., Siggia, E.D., Brivanlou, A.H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077985/
https://ncbi.nlm.nih.gov/pubmed/29795348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0150-y
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