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Self-organization of a human organizer by combined WNT and NODAL signalling

In amniotes, the development of the primitive streak (PS) and its accompanying “organizer” define the first stages of gastrulation. Despite detailed characterization in model organisms, the analogous human structures remain a mystery. We have previously shown that when stimulated with BMP4, micropat...

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Pubblicato in:Nature
Autori principali: Martyn, I., Kanno, T.Y., Ruzo, A., Siggia, E.D., Brivanlou, A.H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077985/
https://ncbi.nlm.nih.gov/pubmed/29795348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0150-y
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