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Mapping cell migrations and fates in a gastruloid model to the human primitive streak

Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS). This is possible because differing levels of BMP, WNT an...

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Detalles Bibliográficos
Publicado en:Development
Autores principales: Martyn, Iain, Siggia, Eric D., Brivanlou, Ali H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765127/
https://ncbi.nlm.nih.gov/pubmed/31427289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.179564
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