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A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization
The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo we used colonies of human embryonic stem cells (hESCs) grown on micropatterned substrate and differentiated with BMP4. These gastruloids recapitulate the embryonic arrangement of the mammali...
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| Publicado no: | Dev Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5113147/ https://ncbi.nlm.nih.gov/pubmed/27746044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.09.016 |
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