A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization

The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo we used colonies of human embryonic stem cells (hESCs) grown on micropatterned substrate and differentiated with BMP4. These gastruloids recapitulate the embryonic arrangement of the mammali...

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Vydáno v:Dev Cell
Hlavní autoři: Etoc, Fred, Metzger, Jakob, Ruzo, Albert, Kirst, Christoph, Yoney, Anna, Ozair, M. Zeeshan, Brivanlou, Ali H., Siggia, Eric D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113147/
https://ncbi.nlm.nih.gov/pubmed/27746044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.09.016
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