Metabolic modeling and response surface analysis of an Escherichia coli strain engineered for shikimic acid production

BACKGROUND: Classic metabolic engineering strategies often induce significant flux imbalances to microbial metabolism, causing undesirable outcomes such as suboptimal conversion of substrates to products. Several mathematical frameworks have been developed to understand the physiological and metabol...

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Detalhes bibliográficos
Publicado no:BMC Syst Biol
Main Authors: Martínez, Juan A., Rodriguez, Alberto, Moreno, Fabian, Flores, Noemí, Lara, Alvaro R., Ramírez, Octavio T., Gosset, Guillermo, Bolivar, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233605/
https://ncbi.nlm.nih.gov/pubmed/30419897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-018-0632-4
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