Metabolic modeling and response surface analysis of an Escherichia coli strain engineered for shikimic acid production

BACKGROUND: Classic metabolic engineering strategies often induce significant flux imbalances to microbial metabolism, causing undesirable outcomes such as suboptimal conversion of substrates to products. Several mathematical frameworks have been developed to understand the physiological and metabol...

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Опубликовано в: :BMC Syst Biol
Главные авторы: Martínez, Juan A., Rodriguez, Alberto, Moreno, Fabian, Flores, Noemí, Lara, Alvaro R., Ramírez, Octavio T., Gosset, Guillermo, Bolivar, Francisco
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233605/
https://ncbi.nlm.nih.gov/pubmed/30419897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-018-0632-4
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