Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date, but the precise NAADP/Ca(2+) signalling mechanisms are still controversial. We report the synthesis of small-molecule inhibitors of NAADP-induced Ca(2+) release based upon the ni...

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Publicat a:Sci Rep
Autors principals: Zhang, Bo, Watt, Joanna M, Cordiglieri, Chiara, Dammermann, Werner, Mahon, Mary F., Flügel, Alexander, Guse, Andreas H., Potter, Barry V. L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233153/
https://ncbi.nlm.nih.gov/pubmed/30425261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34917-3
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