NAADP-mediated Ca(2+) signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

The nucleotide NAADP was recently discovered as a second messenger involved in the initiation and propagation of Ca(2+) signaling in lymphoma T cells, but its impact on primary T cell function is still unknown. An optimized, synthetic, small molecule inhibitor of NAADP action, termed BZ194, was desi...

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Main Authors: Dammermann, Werner, Zhang, Bo, Nebel, Merle, Cordiglieri, Chiara, Odoardi, Francesca, Kirchberger, Tanja, Kawakami, Naoto, Dowden, James, Schmid, Frederike, Dornmair, Klaus, Hohenegger, Martin, Flügel, Alexander, Guse, Andreas H., Potter, Barry V. L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697110/
https://ncbi.nlm.nih.gov/pubmed/19541638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809997106
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