2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis

Ca(2+) signaling is one of the essential signaling systems for T lymphocyte activation, the latter being an essential step in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Store-operated Ca(2+) entry (SOCE) ensures long lasting Ca(2+) signaling and is of utmost importance...

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Veröffentlicht in:Biochim Biophys Acta Mol Cell Res
Hauptverfasser: Hosang, Leon, Löhndorf, Anke, Dohle, Wolfgang, Rosche, Anette, Marry, Stephen, Diercks, Björn-Philipp, Müller-Kirschbaum, Lukas C., Flügel, Lioba T., Potter, Barry V.L., Odoardi, Francesca, Guse, Andreas H., Flügel, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2023
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614598/
https://ncbi.nlm.nih.gov/pubmed/37150482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2023.119485
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