Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray

Adequate pain management remains an unmet medical need. We previously revealed an opioid-independent analgesic mechanism mediated by orexin 1 receptor (OX1R)-initiated 2-arachidonoylglycerol (2-AG) signaling in the ventrolateral periaqueductal gray (vlPAG). Here, we found that low-frequency median n...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chen, Yi-Hung, Lee, Hsin-Jung, Lee, Ming Tatt, Wu, Ya-Ting, Lee, Yen-Hsien, Hwang, Ling-Ling, Hung, Ming-Shiu, Zimmer, Andreas, Mackie, Ken, Chiou, Lih-Chu
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233149/
https://ncbi.nlm.nih.gov/pubmed/30348772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807991115
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars