Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray

Adequate pain management remains an unmet medical need. We previously revealed an opioid-independent analgesic mechanism mediated by orexin 1 receptor (OX1R)-initiated 2-arachidonoylglycerol (2-AG) signaling in the ventrolateral periaqueductal gray (vlPAG). Here, we found that low-frequency median n...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, Yi-Hung, Lee, Hsin-Jung, Lee, Ming Tatt, Wu, Ya-Ting, Lee, Yen-Hsien, Hwang, Ling-Ling, Hung, Ming-Shiu, Zimmer, Andreas, Mackie, Ken, Chiou, Lih-Chu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233149/
https://ncbi.nlm.nih.gov/pubmed/30348772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807991115
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