Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

Extracellular vesicles (EVs) have been implicated in the development and progression of hematological malignancies. We thus examined serum samples from patients with systemic mastocytosis (SM) and found EVs with a mast cell signature including the presence of tryptase, FcεRI, MRGX2, and KIT. The con...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kim, Do-Kyun, Cho, Young-Eun, Komarow, Hirsh D., Bandara, Geethani, Song, Byoung-Joon, Olivera, Ana, Metcalfe, Dean D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233074/
https://ncbi.nlm.nih.gov/pubmed/30352845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809938115
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