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Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

Extracellular vesicles (EVs) have been implicated in the development and progression of hematological malignancies. We thus examined serum samples from patients with systemic mastocytosis (SM) and found EVs with a mast cell signature including the presence of tryptase, FcεRI, MRGX2, and KIT. The con...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Kim, Do-Kyun, Cho, Young-Eun, Komarow, Hirsh D., Bandara, Geethani, Song, Byoung-Joon, Olivera, Ana, Metcalfe, Dean D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233074/
https://ncbi.nlm.nih.gov/pubmed/30352845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809938115
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