Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production

Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved are not well understood. Since systemic masto...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Tobío, Araceli, Bandara, Geethani, Morris, Denise A., Kim, Do-Kyun, O’Connell, Michael P., Komarow, Hirsh D., Carter, Melody C., Smrz, Daniel, Metcalfe, Dean D., Olivera, Ana
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939509/
https://ncbi.nlm.nih.gov/pubmed/30948489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.212126
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