HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection

The linear ubiquitin chain assembly complex (LUBAC), composed of heme-oxidized IRP2 ubiquitin ligase 1 (HOIL1), HOIL1-interacting protein (HOIP), and SHANK-associated RH domain-interacting protein (SHARPIN), is a crucial regulator of multiple immune signaling pathways. In humans, HOIL1 or HOIP defic...

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Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: MacDuff, Donna A., Baldridge, Megan T., Qaqish, Arwa M., Nice, Timothy J., Darbandi, Azad D., Hartley, Victoria L., Peterson, Stefan T., Miner, Jonathan J., Iwai, Kazuhiro, Virgin, Herbert W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2018
Aiheet:
Cellular Response to Infection
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232484/
https://ncbi.nlm.nih.gov/pubmed/30209176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01368-18
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