Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s) upon which IFN-λ acts to exert its antiviral...

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Vydáno v:J Virol
Hlavní autoři: Baldridge, Megan T., Lee, Sanghyun, Brown, Judy J., McAllister, Nicole, Urbanek, Kelly, Dermody, Terence S., Nice, Timothy J., Virgin, Herbert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355594/
https://ncbi.nlm.nih.gov/pubmed/28077655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02079-16
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