Reovirus Neurotropism and Virulence Are Dictated by Sequences in the Head Domain of the Viral Attachment Protein

Viral capsid components that bind cellular receptors mediate critical functions in viral tropism and disease pathogenesis. Mammalian orthoreoviruses (reoviruses) spread systemically in newborn mice to cause serotype-specific disease in the central nervous system (CNS). Serotype 1 (T1) reovirus infec...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Sutherland, Danica M., Aravamudhan, Pavithra, Dietrich, Melanie H., Stehle, Thilo, Dermody, Terence S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232475/
https://ncbi.nlm.nih.gov/pubmed/30209169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00974-18
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