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Reovirus Neurotropism and Virulence Are Dictated by Sequences in the Head Domain of the Viral Attachment Protein

Viral capsid components that bind cellular receptors mediate critical functions in viral tropism and disease pathogenesis. Mammalian orthoreoviruses (reoviruses) spread systemically in newborn mice to cause serotype-specific disease in the central nervous system (CNS). Serotype 1 (T1) reovirus infec...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sutherland, Danica M., Aravamudhan, Pavithra, Dietrich, Melanie H., Stehle, Thilo, Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232475/
https://ncbi.nlm.nih.gov/pubmed/30209169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00974-18
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