Human adipose glycerol flux is regulated by a pH gate in AQP10

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal...

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發表在:Nat Commun
Main Authors: Gotfryd, Kamil, Mósca, Andreia Filipa, Missel, Julie Winkel, Truelsen, Sigurd Friis, Wang, Kaituo, Spulber, Mariana, Krabbe, Simon, Hélix-Nielsen, Claus, Laforenza, Umberto, Soveral, Graça, Pedersen, Per Amstrup, Gourdon, Pontus
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232157/
https://ncbi.nlm.nih.gov/pubmed/30420639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07176-z
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