Human adipose glycerol flux is regulated by a pH gate in AQP10

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Gotfryd, Kamil, Mósca, Andreia Filipa, Missel, Julie Winkel, Truelsen, Sigurd Friis, Wang, Kaituo, Spulber, Mariana, Krabbe, Simon, Hélix-Nielsen, Claus, Laforenza, Umberto, Soveral, Graça, Pedersen, Per Amstrup, Gourdon, Pontus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232157/
https://ncbi.nlm.nih.gov/pubmed/30420639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07176-z
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