Human adipose glycerol flux is regulated by a pH gate in AQP10

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gotfryd, Kamil, Mósca, Andreia Filipa, Missel, Julie Winkel, Truelsen, Sigurd Friis, Wang, Kaituo, Spulber, Mariana, Krabbe, Simon, Hélix-Nielsen, Claus, Laforenza, Umberto, Soveral, Graça, Pedersen, Per Amstrup, Gourdon, Pontus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232157/
https://ncbi.nlm.nih.gov/pubmed/30420639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07176-z
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