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Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library

Macrocyclic peptides are capable of binding to flat protein surfaces such as the interfaces of protein–protein interactions with antibody-like affinity and specificity, but generally lack cell permeability in order to access intracellular targets. In this work, we designed and synthesized a large co...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Am Chem Soc
Main Authors: Rhodes, Curran A., Dougherty, Patrick G., Cooper, Jahan K., Qian, Ziqing, Lindert, Steffen, Wang, Qi-En, Pei, Dehua
פורמט: Artigo
שפה:Inglês
יצא לאור: 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231237/
https://ncbi.nlm.nih.gov/pubmed/30176143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b06738
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