Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization

Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. Here, we report a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fuse...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Qian, Ziqing, Rhodes, Curran A., McCroskey, Lucas C., Wen, Jin, Appiah-Kubi, George, Wang, David J., Guttridge, Denis C., Pei, Dehua
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296932/
https://ncbi.nlm.nih.gov/pubmed/28035784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201610888
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