Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization

Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. Here, we report a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fuse...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Qian, Ziqing, Rhodes, Curran A., McCroskey, Lucas C., Wen, Jin, Appiah-Kubi, George, Wang, David J., Guttridge, Denis C., Pei, Dehua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296932/
https://ncbi.nlm.nih.gov/pubmed/28035784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201610888
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