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Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization
Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. Here, we report a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fuse...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296932/ https://ncbi.nlm.nih.gov/pubmed/28035784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201610888 |
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