mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity

Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and lymphocyte proliferation. It is inhibited by the tuberous sclerosis complex (TSC), a heterodimer of TSC1 and TSC2. Deletion of either gene results in robust activation of mTORC1. Mature B cells reside in the s...

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Pubblicato in:Immunology
Autori principali: Meena, Naresh Kumar, Pattanayak, Shakti Prasad, Ben‐Nun, Yael, Benhamron, Sandrine, Kumar, Saran, Merquiol, Emmanuelle, Hövelmeyer, Nadine, Blum, Galia, Tirosh, Boaz
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231019/
https://ncbi.nlm.nih.gov/pubmed/30144045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12996
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