Detecting cathepsin activity in human osteoarthritis via activity-based probes

INTRODUCTION: Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the causal role of cathepsins in OA, monitoring their specific activity could provide means for assessing OA severity. To this end, w...

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Pubblicato in:Arthritis Res Ther
Autori principali: Ben-Aderet, Louisa, Merquiol, Emmanuelle, Fahham, Duha, Kumar, Ashok, Reich, Eli, Ben-Nun, Yael, Kandel, Leonid, Haze, Amir, Liebergall, Meir, Kosińska, Marta K, Steinmeyer, Juergen, Turk, Boris, Blum, Galia, Dvir-Ginzberg, Mona
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415352/
https://ncbi.nlm.nih.gov/pubmed/25889265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0586-5
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