Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes

Changes in the content of aggrecan, an essential proteoglycan of articular cartilage, have been implicated in the pathophysiology of osteoarthritis (OA), a prevalent age‐related, degenerative joint disease. Here, we examined the effect of SOX9 acetylation on ACAN transactivation in the context of os...

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Foilsithe in:Aging Cell
Main Authors: Bar Oz, Michal, Kumar, Ashok, Elayyan, Jinan, Reich, Eli, Binyamin, Milana, Kandel, Leonid, Liebergall, Meir, Steinmeyer, Juergen, Lefebvre, Veronique, Dvir‐Ginzberg, Mona
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854920/
https://ncbi.nlm.nih.gov/pubmed/26910618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12456
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