Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes

Changes in the content of aggrecan, an essential proteoglycan of articular cartilage, have been implicated in the pathophysiology of osteoarthritis (OA), a prevalent age‐related, degenerative joint disease. Here, we examined the effect of SOX9 acetylation on ACAN transactivation in the context of os...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Bar Oz, Michal, Kumar, Ashok, Elayyan, Jinan, Reich, Eli, Binyamin, Milana, Kandel, Leonid, Liebergall, Meir, Steinmeyer, Juergen, Lefebvre, Veronique, Dvir‐Ginzberg, Mona
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854920/
https://ncbi.nlm.nih.gov/pubmed/26910618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12456
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