Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

Signaling pathways mediated by the mechanistic target of rapamycin (mTOR) play key roles in aging and age-related diseases. As a downstream protein of mTOR, transcription factor EB (TFEB) controls lysosome biogenesis and cellular trafficking, processes that are essential for the functions of phagocy...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Huang, Yi, Chen, Yan, Shaw, Amanda Marie, Goldfine, Howard, Tian, Junqiang, Cai, Jiyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230393/
https://ncbi.nlm.nih.gov/pubmed/30510622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5073420
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