mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular components represent unmet medical conditions for which the identification of actionable targets is urgently needed. Here we identify a pharmacologically actionable pathway that controls cellular clearance via A...

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Vydáno v:Nat Commun
Hlavní autoři: Palmieri, Michela, Pal, Rituraj, Nelvagal, Hemanth R., Lotfi, Parisa, Stinnett, Gary R., Seymour, Michelle L., Chaudhury, Arindam, Bajaj, Lakshya, Bondar, Vitaliy V., Bremner, Laura, Saleem, Usama, Tse, Dennis Y., Sanagasetti, Deepthi, Wu, Samuel M., Neilson, Joel R., Pereira, Fred A., Pautler, Robia G., Rodney, George G., Cooper, Jonathan D., Sardiello, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303831/
https://ncbi.nlm.nih.gov/pubmed/28165011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14338
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