EFFECT OF LONG-TERM POLYPHARMACY AND THE DRUG BURDEN INDEX (DBI) ON CARDIAC FUNCTION AND FIBROSIS IN AGED MICE

Polypharmacy (use of ≥ 5 medications) and Drug Burden Index (DBI: measures cumulative exposure to anticholinergic and sedative drugs) impair function in older adults. Preclinical studies can provide a mechanistic understanding. We aim to evaluate the effect of chronic polypharmacy, medications with...

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Détails bibliographiques
Publié dans:Innov Aging
Auteurs principaux: Tran, T, Mach, J, Gemikonakli, G, Howlett, S, deCabo, R, Le Couteur, D, Hilmer, S
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Abstracts
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230101/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.371
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