EFFECT OF CHRONIC POLYPHARMACY AND THE DRUG BURDEN INDEX (DBI) ON PHYSICAL FUNCTION IN AGED MICE

Increasing DBI (measure of patient’s total exposure to anticholinergics and sedatives) is associated with impaired physical function in observational studies of older adults. We aim to determine the effect of polypharmacy (use of ≥ 5 drugs) and increasing DBI on functional outcomes in aged mice. Fro...

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Bibliographic Details
Published in:Innov Aging
Main Authors: Mach, J., Logan, C., Gemikonakli, G., Kane, A.E., Howlett, S.E., de Cabo, R., Le Couteur, D.G., Hilmer, S.N.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6184776/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igx004.3216
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