Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

It remains unclear whether PAX6 acts as a crucial transcription factor for lung cancer stem cell (CSC) traits. We demonstrate that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma (LUAD). Mechanistically, PAX6 promotes GLI transcription, resulti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ooki, Akira, Dinalankara, Wikum, Marchionni, Luigi, Tsay, Jun-Chieh J., Goparaju, Chandra, Maleki, Zahra, Rom, William N., Pass, Harvey I., Hoque, Mohammad O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226336/
https://ncbi.nlm.nih.gov/pubmed/29980786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0373-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados