Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

It remains unclear whether PAX6 acts as a crucial transcription factor for lung cancer stem cell (CSC) traits. We demonstrate that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma (LUAD). Mechanistically, PAX6 promotes GLI transcription, resulti...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Ooki, Akira, Dinalankara, Wikum, Marchionni, Luigi, Tsay, Jun-Chieh J., Goparaju, Chandra, Maleki, Zahra, Rom, William N., Pass, Harvey I., Hoque, Mohammad O.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226336/
https://ncbi.nlm.nih.gov/pubmed/29980786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0373-2
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker