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Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

It remains unclear whether PAX6 acts as a crucial transcription factor for lung cancer stem cell (CSC) traits. We demonstrate that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma (LUAD). Mechanistically, PAX6 promotes GLI transcription, resulti...

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Библиографические подробности
Опубликовано в: :Oncogene
Главные авторы: Ooki, Akira, Dinalankara, Wikum, Marchionni, Luigi, Tsay, Jun-Chieh J., Goparaju, Chandra, Maleki, Zahra, Rom, William N., Pass, Harvey I., Hoque, Mohammad O.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226336/
https://ncbi.nlm.nih.gov/pubmed/29980786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0373-2
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