No Pharmacokinetic Interactions Between Elbasvir or Grazoprevir and Methadone in Participants Receiving Maintenance Opioid Agonist Therapy

We conducted two phase I trials to evaluate the pharmacokinetic interactions between elbasvir (EBR), grazoprevir (GZR), and methadone (MK‐8742‐P010 and MK‐5172‐P030) in non‐hepatitis C virus (HCV)‐infected participants on methadone maintenance therapy. Coadministration of EBR or GZR with methadone h...

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Bibliographic Details
Published in:Clin Transl Sci
Main Authors: Feng, Hwa‐Ping, Guo, Zifang, Caro, Luzelena, Marshall, William L., Liu, Fang, Panebianco, Deborah, Vaddady, Pavan, Reitmann, Christina, Jumes, Patricia, Wolford, Dennis, Fraser, Iain, Valesky, Robert, Martinho, Monika, Butterton, Joan R., Iwamoto, Marian, Webster, Lynn, Yeh, Wendy W.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226122/
https://ncbi.nlm.nih.gov/pubmed/30040872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12564
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