Effect of Hepatic Impairment on the Pharmacokinetics of Grazoprevir, a Hepatitis C Virus Protease Inhibitor

Grazoprevir (GZR) plus elbasvir is an approved treatment for chronic infection with hepatitis C virus (HCV) genotype 1 or 4. HCV infection complications include liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The objective of this study was to evaluate the pharmacokinetics an...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Caro, Luzelena, Wenning, Larissa, Guo, Zifang, Fraser, Iain P., Fandozzi, Christine, Talaty, Jennifer, Panebianco, Deborah, Ho, Maureen, Uemura, Naoto, Reitmann, Christina, Angus, Peter, Gane, Edward, Marbury, Thomas, Smith, William B., Iwamoto, Marian, Butterton, Joan R., Yeh, Wendy W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700330/
https://ncbi.nlm.nih.gov/pubmed/28947470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00813-17
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