Esophageal organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification

Tracheal and esophageal disorders are prevalent in humans and are difficult to accurately model in mice. We therefore established a three-dimensional organoid model of esophageal development through directed differentiation of human pluripotent stem cells. Sequential manipulation of BMP, WNT, and RA...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Stem Cell
Main Authors: Trisno, Stephen L., Philo, Katherine E. D., McCracken, Kyle W., Cata, Emily M., RuizTorres, Sonya, Rankin, Scott A., Han, Lu, Nasr, Talia, Chatuvedi, Praneet, Rothenberg, Marc E., Mandegar, Mohammad A., Wells, Susanne I., Zorn, Aaron M., Wells, James M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2018
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225525/
https://ncbi.nlm.nih.gov/pubmed/30244869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.008
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