Esophageal organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification

Tracheal and esophageal disorders are prevalent in humans and are difficult to accurately model in mice. We therefore established a three-dimensional organoid model of esophageal development through directed differentiation of human pluripotent stem cells. Sequential manipulation of BMP, WNT, and RA...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Trisno, Stephen L., Philo, Katherine E. D., McCracken, Kyle W., Cata, Emily M., RuizTorres, Sonya, Rankin, Scott A., Han, Lu, Nasr, Talia, Chatuvedi, Praneet, Rothenberg, Marc E., Mandegar, Mohammad A., Wells, Susanne I., Zorn, Aaron M., Wells, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225525/
https://ncbi.nlm.nih.gov/pubmed/30244869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.008
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