Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9(+) tracheal chondrocytes

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Nasr, Talia, Holderbaum, Andrea M., Chaturvedi, Praneet, Agarwal, Kunal, Kinney, Jessica L., Daniels, Keziah, Trisno, Stephen L., Ustiyan, Vladimir, Shannon, John M., Wells, James M., Sinner, Debora, Kalinichenko, Vladimir V., Zorn, Aaron M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875488/
https://ncbi.nlm.nih.gov/pubmed/33328171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.046573
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