Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9(+) tracheal chondrocytes

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mou...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Dis Model Mech
मुख्य लेखकों: Nasr, Talia, Holderbaum, Andrea M., Chaturvedi, Praneet, Agarwal, Kunal, Kinney, Jessica L., Daniels, Keziah, Trisno, Stephen L., Ustiyan, Vladimir, Shannon, John M., Wells, James M., Sinner, Debora, Kalinichenko, Vladimir V., Zorn, Aaron M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Company of Biologists Ltd 2021
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875488/
https://ncbi.nlm.nih.gov/pubmed/33328171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.046573
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