Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts

Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS the mutation G608G leads to the formation of...

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Vydáno v:Biogerontology
Hlavní autoři: Bikkul, Mehmet U., Clements, Craig S., Godwin, Lauren S., Goldberg, Martin W., Kill, Ian R., Bridger, Joanna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223735/
https://ncbi.nlm.nih.gov/pubmed/29907918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-018-9758-4
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