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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
Hutchinson Gilford progeria syndrome is a fatal disorder characterized by accelerated aging, bone resorption and atherosclerosis, caused by a LMNA mutation which produces progerin, a mutant lamin A precursor. Progeria cells display progerin and prelamin A nuclear accumulation, altered histone methyl...
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| Udgivet i: | Oncotarget |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4745772/ https://ncbi.nlm.nih.gov/pubmed/26359359 |
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