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Macrophage-Targeted Drugamers With Enzyme-Cleavable Linkers Deliver High Intracellular Drug Dosing and Sustained Drug Pharmacokinetics Against Alveolar Pulmonary Infections

Intracellular bacterial infections localized to the lung alveolar macrophage (AM) remain one of the most challenging settings for antimicrobial therapy. Current systemic antibiotic treatment fails to deliver sustained doses to intracellular bacterial reservoirs, which necessitates prolonged treatmen...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Control Release
मुख्य लेखकों: Su, Fang-Yi, Srinivasan, Selvi, Lee, Brian, Chen, Jasmin, Convertine, Anthony J., West, T. Eoin, Ratner, Daniel M., Skerrett, Shawn J., Stayton, Patrick S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223132/
https://ncbi.nlm.nih.gov/pubmed/30099019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.08.014
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