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Data-Driven Exploration of Selectivity and Off-Target Activities of Designated Chemical Probes

Chemical probes are of central relevance for chemical biology. To unambiguously explore the role of target proteins in triggering or mediating biological functions, small molecules used as probes should ideally be target-specific; at least, they should have sufficiently high selectivity for a primar...

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Foilsithe in:Molecules
Main Authors: Miljković, Filip, Bajorath, Jürgen
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222907/
https://ncbi.nlm.nih.gov/pubmed/30249057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102434
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