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Data-Driven Exploration of Selectivity and Off-Target Activities of Designated Chemical Probes

Chemical probes are of central relevance for chemical biology. To unambiguously explore the role of target proteins in triggering or mediating biological functions, small molecules used as probes should ideally be target-specific; at least, they should have sufficiently high selectivity for a primar...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Miljković, Filip, Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222907/
https://ncbi.nlm.nih.gov/pubmed/30249057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102434
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