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Reconciling Selectivity Trends from a Comprehensive Kinase Inhibitor Profiling Campaign with Known Activity Data

[Image: see text] Kinase inhibitors are among the most intensely investigated compounds in medicinal chemistry and drug development. Profiling experiments and kinome screens reveal binding characteristics of kinase inhibitors and lead to better understanding of selectivity and promiscuity patterns....

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Bibliografische gegevens
Gepubliceerd in:ACS Omega
Hoofdauteurs: Miljković, Filip, Bajorath, Jürgen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045376/
https://ncbi.nlm.nih.gov/pubmed/30023860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00243
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