Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition

Human parietal epithelial cells (PECs) are progenitor cells that sustain podocyte homeostasis. We hypothesized that the lack of apolipoprotein (APO) L1 ensures the PEC phenotype, but its induction initiates PEC transition (expression of podocyte markers). APOL1 expression and down-regulation of miR1...

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Publié dans:Am J Pathol
Auteurs principaux: Kumar, Vinod, Vashistha, Himanshu, Lan, Xiqian, Chandel, Nirupama, Ayasolla, Kamesh, Shoshtari, Seyedeh Shadafarin Marashi, Aslam, Rukhsana, Paliwal, Nitpriya, Abbruscato, Frank, Mikulak, Joanna, Popik, Waldemar, Atta, Mohamed G., Chander, Praveen N., Malhotra, Ashwani, Meyer-Schwesinger, Catherine, Skorecki, Karl, Singhal, Pravin C.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222279/
https://ncbi.nlm.nih.gov/pubmed/30201495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.07.025
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