BMI1 enables interspecies chimerism with human pluripotent stem cells

Human pluripotent stem cells (hPSCs) exhibit very limited contribution to interspecies chimeras. One explanation is that the conventional hPSCs are in a primed state and so unable  to form chimeras in pre-implantation embryos. Here, we show that the conventional hPSCs undergo rapid apoptosis when in...

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Publicat a:Nat Commun
Autors principals: Huang, Ke, Zhu, Yanling, Ma, Yanlin, Zhao, Bentian, Fan, Nana, Li, Yuhang, Song, Hong, Chu, Shilong, Ouyang, Zhen, Zhang, Quanjun, Xing, Qi, Lai, Chengdan, Li, Nan, Zhang, Tian, Gu, Jiaming, Kang, Baoqiang, Shan, Yongli, Lai, Keyu, Huang, Wenhao, Mai, Yuchan, Wang, Qing, Li, Jinbing, Lin, Aiping, Zhang, Yanqi, Zhong, Xiaofen, Liao, Baojian, Lai, Liangxue, Chen, Jiekai, Pei, Duanqing, Pan, Guangjin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220315/
https://ncbi.nlm.nih.gov/pubmed/30405129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07098-w
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